Postdoc - Biomedicine

Bio

I graduated from Cairo University with a medical degree. After graduation, I spent a year traveling and volunteering with youth organizations to bring a bit of fun and nature to underserved school kids. In 2016, I joined a lab in Jinju, South Korea, to do research. I studied autophagy and its role in development and disease using high-throughput sequencing data. I developed several open-source R packages and Shiny apps to work with gene expression and regulation data. Now I am building an open-source platform to discover and repurpose drugs for cancer. I also try my hand at the exciting field of cancer evolution. I spend most days between the Linux terminal, the R console, and the LaTex editor.

Eduction

Interests

  • Cancer evolution
  • Drug discovery and repurposing
  • Regulation of gene expression
  • Autophagy

Projects


Task specialization in evolving cancer cells


Studying task specialization and trade-offs in evolving cancer cells.


Perturbing biological networks in cancer cell lines


Studying causal biological networks and their perturbation using existing biological knowledge and data.


Chromatin segmentation analysis


Performing chromatin segmentation analysis in R.


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Publications


Tissue-specific gene expression in obese hyperglycemic mice


Mahmoud Ahmed, Omar Elashkar, Jong Youl Lee, Eun Ae Jeong, Kyung Eun Kim, Gu Seob Roh, Deok Ryong Kim


All Life, Taylor & Francis, 2022, pp. 555-561


Hierarchical Regulation of Autophagy During Adipocyte Differentiation


Mahmoud Ahmed, Trang Huyen Lai, Trang Minh Pham, Sahib Zada, Omar Elashkar, Jin Seok Hwang, Deok Ryong Kim


PLoS ONE, vol. 17(1), 2022 6, pp. e0250865


target: an R package to predict combined function of transcription factors


Mahmoud Ahmed, Deok Ryong Kim


F1000Research, 2021


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Posts


Jan 23, 2022


The non-genetic determinants in cancer evolution


When one lines up the genomes of related species, they vary in more than the protein-coding sequences. In fact, most differences fall outside these regions, given the small fraction they represent. Genomes differ with respect to sequences that regulate...


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Jan 16, 2022


The evolution of self-consumption


To study the evolution of a body part or a trait, one needs to address two questions. First, what is the trait for? Second, how could it evolve by small steps that gave some advantage to the organism that carried them? It is also necessary to suggest a...


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Jan 7, 2022


Cancer evolution by non-Darwinian mechanisms


In the Darwinian model of cancer evolution, the variations among cancer cells result in differential survival of some clones, which dominate the tumor mass. This view was challenged by discovering that tumors comprised multiple subclones that differ ge...


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Contact


Mahmoud Ahmed


Postdoc


[email protected]

Convergence Medical Science


Gyeongsang National University


Jinju, South Korea