Mahmoud Ahmed

Postdoc - Cancer Genomics
🔔
  • Check out our recent  article on RKIP and metastasis (here)
  • Check out our recent perspective article on using public genomics data (here)
  • Check out our two recent preprints on bioRxiv and medRxiv

Bio

I graduated from Cairo University with a medical degree. After graduation, I spent a year traveling and volunteering with youth organizations to bring some joy and nature to underserved school kids. In 2016, I joined a lab in Jinju, South Korea, to do research. I studied autophagy and its role in development and disease using high-throughput sequencing data. I developed several open-source R packages and Shiny apps to work with gene expression and regulation data. I have recently joined the cancer genomics team at the Institute of Cancer Research in London to work on the genetics of childhood cancer. I spend most days between the Linux terminal, the R console, and the LaTex editor.

Work Experience

  • Postdoctoral Fellow.  The Institute of Cancer Research, UK (2023 - Present)
  • Senior Researcher. Gyeongsang National University, South Korea (2021 - 2023)

Education

  • PhD. Gyeongsang National University - 2021
  • MS. Gyeongsang National University - 2018
  • MBBCh. Cairo University - 2014
  • Lots of online courses

Awards & Fellowships

  • Fellowship. Center for Human Resource Development in Bio-medicine  (2021 - 2022)
  • Young Scientist Program Award. FAOBMB (2021)
  • Young Scientist Program Award. KSBMB (2020 & 2021)
  • Young Pioneer Research Award. Gyeongsang National University (2018 & 2019)

Interests

  • Cancer genomics
  • Drug discovery and repurposing
  • Regulation of gene expression
  • Autophagy in development and disease

Projects


Task specialization in evolving cancer cells


Studying task specialization and trade-offs in evolving cancer cells.


Perturbing biological networks in cancer cell lines


Studying causal biological networks and their perturbation using existing biological knowledge and data.


Transcriptional regulation of RKIP in cancer


Deciphering the regulatory circuits responsible for RKIP loss in different cancer cell models.


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Publications


Editorial: Opportunities and challenges in reusing public genomics data


Mahmoud Ahmed, Deok Ryong Kim

Frontiers in Pharmacology, vol. 14, 2023


Manipulating RKIP reverses the metastatic potential of breast cancer cells


Trang Huyen Lai, Mahmoud Ahmed, Jin Seok Hwang, Md Entaz Bahar, Trang Minh Pham, Jinsung Yang, Wanil Kim, Rizi Firman Maulidi, Dong-Kun Lee, Dong-Hee Kim, Hyun Joon Kim, Deok Ryong Kim

Frontiers in Oncology, vol. 13, 2023


Maximizing the utility of public data


Mahmoud Ahmed, Hyun Joon Kim, Deok Ryong Kim

Frontiers in Genetics, vol. 14, Frontiers Media SA, 2023 Mar


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Posts


Jan 5, 2023

Public data for the public good

The human genome project galvanized the scientific community around an ambitious goal. It produced several crucial discoveries, and a new era of research began. For the first time, it became possible to estimate the number of human genes and compile a ...


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Dec 26, 2022

The evolutionary war — how to beat cancer in its own game

Cancer evolves. That much is known and agreed upon. Researchers still, however, debate the detailed picture of how cancer came to be and why it still plages our species is subject to debate. Studying cancer through an evolutionary lens could provide an...


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Aug 4, 2022

Gene expression adaptation in yeast, mice, and humans

Coding vs. non-coding variants Mutations produce novelty. The kind of novel variants on which selection acts. These variants fall within two broad categories depending on location in the genome: protein-coding and regulatory sequences. The former pro...


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Contact


Mahmoud Ahmed

Postdoc



Genetics & Epidemiology

The Institute of Cancer Research

London, UK


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