Mahmoud Ahmed

Postdoc - Biomedicine

Bio

I graduated from Cairo University with a medical degree. After graduation, I spent a year traveling and volunteering with youth organizations to bring a bit of fun and nature to underserved school kids. In 2016, I joined a lab in Jinju, South Korea, to do research. I studied autophagy and its role in development and disease using high-throughput sequencing data. I developed several open-source R packages and Shiny apps to work with gene expression and regulation data. Now I am building an open-source platform to discover and repurpose drugs for cancer. I also try my hand at the exciting field of cancer evolution. I spend most days between the Linux terminal, the R console, and the LaTex editor.

Eduction

Interests

  • Cancer evolution
  • Drug discovery and repurposing
  • Regulation of gene expression
  • Autophagy

Projects


Task specialization in evolving cancer cells


Studying task specialization and trade-offs in evolving cancer cells.


Perturbing biological networks in cancer cell lines


Studying causal biological networks and their perturbation using existing biological knowledge and data.


Chromatin segmentation analysis


Performing chromatin segmentation analysis in R.


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Publications


target: an R package to predict combined function of transcription factors


Mahmoud Ahmed, Deok Ryong Kim


F1000Research, 2021


LINPS: a database for cancer-cell-specific perturbations of biological networks


Mahmoud Ahmed, Deok Ryong Kim


Database, issue 2021, 2021


A functional network model of the metastasis suppressor RKIP and its regulators in breast cancer cells


Mahmoud Ahmed, Trang Huyen Lai, Deok Ryong Kim


Cancers, vol. 13(23), 2021


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Posts


Jan 16, 2022


The evolution of self-consumption


To study the evolution of a body part or a trait, one needs to address two questions. First, what is the trait for? Second, how could it evolve by small steps that gave some advantage to the organism that carried them? It is also necessary to suggest a...


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Jan 7, 2022


Cancer evolution by non-Darwinian mechanisms


In the Darwinian model of cancer evolution, the variations among cancer cells result in differential survival of some clones, which dominate the tumor mass. This view was challenged by discovering that tumors comprised multiple subclones that differ ge...


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Jan 5, 2022


A cell eating itself, leveraging autophagy to treat cancer


What is autophagy? Autophagy is a process by which the cell can maintain and recycle its components. The process starts by forming a membrane around the target. This structure then is fused with lysosomes which contain enzymes to lyse and degrade the...


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Contact


Mahmoud Ahmed


Postdoc


[email protected]

Convergence Medical Science


Gyeongsang National University


Jinju, South Korea