Mahmoud Ahmed

Postdoc - Biomedicine

Posts


Jan 23, 2022


The non-genetic determinants in cancer evolution


When one lines up the genomes of related species, they vary in more than the protein-coding sequences. In fact, most differences fall outside these regions, given the small fraction they represent. Genomes differ with respect to sequences that regulate...


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Jan 16, 2022


The evolution of self-consumption


To study the evolution of a body part or a trait, one needs to address two questions. First, what is the trait for? Second, how could it evolve by small steps that gave some advantage to the organism that carried them? It is also necessary to suggest a...


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Jan 7, 2022


Cancer evolution by non-Darwinian mechanisms


In the Darwinian model of cancer evolution, the variations among cancer cells result in differential survival of some clones, which dominate the tumor mass. This view was challenged by discovering that tumors comprised multiple subclones that differ ge...


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Jan 5, 2022


A cell eating itself, leveraging autophagy to treat cancer


What is autophagy? Autophagy is a process by which the cell can maintain and recycle its components. The process starts by forming a membrane around the target. This structure then is fused with lysosomes which contain enzymes to lyse and degrade the...


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Dec 3, 2021


My research approach in grad school - a research statement


Overview During my graduate school training, I decided to focus on using publicly available high-throughput data. This, on the one hand, was to reduce the opportunity cost and, on the other, increase the utility of existing datasets. My strategy cons...


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Jun 1, 2021


The archetypes of cancer


Evolutionary thinking is a powerful tool kit for studying development and disease. Prominent areas of relevance are the development of functional organs and the mismatch between their initial conditions and the current environments and lifestyles. Thes...


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Oct 10, 2020


Six things go wrong for cancer to grow


Cancer isn't a single disease but rather a multitude of conditions that arise at varying ages, grow at different rates, and manifest in numerous ways. However, the cells that constitute these tumors share plenty of features and employ similar strategie...


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