Mahmoud Ahmed

Postdoc - Cancer Genomics

Life history dynamics of evolving tumors: insights into task specialization, trade-offs, and tumor heterogeneity


Journal article


Mahmoud Ahmed, Deok Ryong Kim
Cancer Cell International , vol. 24(1), BioMed Central Ltd, 2024 Dec


Cite

Cite

APA   Click to copy
Ahmed, M., & Kim, D. R. (2024). Life history dynamics of evolving tumors: insights into task specialization, trade-offs, and tumor heterogeneity. Cancer Cell International , 24(1). https://doi.org/10.1186/s12935-024-03538-4


Chicago/Turabian   Click to copy
Ahmed, Mahmoud, and Deok Ryong Kim. “Life History Dynamics of Evolving Tumors: Insights into Task Specialization, Trade-Offs, and Tumor Heterogeneity.” Cancer Cell International 24, no. 1 (December 2024).


MLA   Click to copy
Ahmed, Mahmoud, and Deok Ryong Kim. “Life History Dynamics of Evolving Tumors: Insights into Task Specialization, Trade-Offs, and Tumor Heterogeneity.” Cancer Cell International , vol. 24, no. 1, BioMed Central Ltd, Dec. 2024, doi:10.1186/s12935-024-03538-4.


BibTeX   Click to copy

@article{ahmed2024a,
  title = {Life history dynamics of evolving tumors: insights into task specialization, trade-offs, and tumor heterogeneity},
  year = {2024},
  month = dec,
  issue = {1},
  journal = {Cancer Cell International },
  publisher = {BioMed Central Ltd},
  volume = {24},
  doi = {10.1186/s12935-024-03538-4},
  author = {Ahmed, Mahmoud and Kim, Deok Ryong},
  month_numeric = {12}
}

Abstract

The evolution of cancer cells parallels species evolution in numerous ways. Variations arise and spread under the pressure of competition between cancer cells. Current investigations of tumor evolution echo earlier debates between biologists. These include the role of non-Darwinian mechanisms, the contribution of neutral evolution, and life history dynamics. The trade-off between proliferation and metastasis is the most well-studied application of life history theory to cancer evolution. This article briefly introduces some parallels between cancer and species evolution, focusing on the life history of evolving tumors. Next, we review evidence from simulation and experimental studies supporting task specialization and trade-offs in cancer. We also cover recent work on inferring tumor tasks from data. We then turn to the implications of multi-tasking and the utility of the theory in explaining critical aspects of tumor heterogeneity. Finally, we discuss some of the criticism and future directions of this research topic.



Share


Follow this website


You need to create an Owlstown account to follow this website.


Sign up

Already an Owlstown member?

Log in