- MTDH is a novel transcriptional co-factor that controls RKIP transcription, which is essential for breast cancer progression.
- VEZF1 and ERCC6 simultaneously target RKIP and one or more of the autophagy genes in prostate cancer.
- RKIP and its co-expressed autophagy genes are co-regulated by common transcription factors as part of the same functional unit in developing prostate cancer.
- The metastasis suppressor RKIP is on the receiving end of two significant regulatory mechanisms. One involves RELA (transcription factor P65) and SNAI1, which were previously reported to inhibit PEBP1. The other involves the estrogen receptor (ESR1), which induces PEBP1 through the kinase NME1.
- Pharmacologically manipulating RKIP reverses the metastatic potential of breast cancer cells.
Mahmoud Ahmed, Trang Huyen Lai, Sahib Zada, Jin Seok Hwang, Trang Minh Pham, Miyong Yun, Deok Ryong Kim
Cancers, vol. 10(8), 2018 Jul 16
Mahmoud Ahmed, Deok Ryong KIm
Prognostic and Therapeutic Applications of RKIP in Cancer, Benjamin Bonavida, Stavroula Baritaki, chapter 15, 1st ed., vol. 1, Academic Press, 2020, pp. 277-293
Trang Huyen Lai, Mahmoud Ahmed, Jin Seok Hwang, Sahib Zada, Trang Minh Pham, Omar Elashkar, Deok Ryong Kim
International Journal of Molecular Sciences, vol. 22(6), 2021 Feb 17