Anti-cancer effect of RKIP via modulating autophagy during metastasis

Book chapter

Mahmoud Ahmed, Deok Ryong KIm
Prognostic and Therapeutic Applications of RKIP in Cancer, Benjamin Bonavida, Stavroula Baritaki, chapter 15, 1st ed., vol. 1, Academic Press, 2020, pp. 277-293

DOI: 10.1016/B978-0-12-819612-0.00015-8

View Online

Cite

APA Click to copy
Ahmed, M., & KIm, D. R. (2020). Anti-cancer effect of RKIP via modulating autophagy during metastasis. In B. Bonavida & S. Baritaki (Eds.) (1st ed., Vol. 1, pp. 277–293). Academic Press. https://doi.org/10.1016/B978-0-12-819612-0.00015-8

Chicago/Turabian Click to copy
Ahmed, Mahmoud, and Deok Ryong KIm. “Anti-Cancer Effect of RKIP via Modulating Autophagy during Metastasis.” In , edited by Benjamin Bonavida and Stavroula Baritaki, 1:277–293. 1st ed. Prognostic and Therapeutic Applications of RKIP in Cancer. Academic Press, 2020.

MLA Click to copy
Ahmed, Mahmoud, and Deok Ryong KIm. Anti-Cancer Effect of RKIP via Modulating Autophagy during Metastasis. Edited by Benjamin Bonavida and Stavroula Baritaki, 1st ed., vol. 1, Academic Press, 2020, pp. 277–93, doi:10.1016/B978-0-12-819612-0.00015-8.

BibTeX Click to copy

@inbook{mahmoud2020a,
  title = {Anti-cancer effect of RKIP via modulating autophagy during metastasis},
  year = {2020},
  chapter = {15},
  edition = {1},
  pages = {277-293},
  publisher = {Academic Press},
  series = {Prognostic and Therapeutic Applications of RKIP in Cancer},
  volume = {1},
  doi = {10.1016/B978-0-12-819612-0.00015-8},
  author = {Ahmed, Mahmoud and KIm, Deok Ryong},
  editor = {Bonavida, Benjamin and Baritaki, Stavroula}
}

Abstract

Raf kinase inhibitory protein (RKIP) is under extensive study for its anti-metastatic taking role, and it contributes to the regulation of several signaling pathways and physiological processes in cells. Indeed, the loss or low expression of RKIP in cancer tissues results in aggressive metastatic phenotypes. Besides, some studies suggest that RKIP negatively regulates autophagy, a catabolic pathway to supply energy for the survival of cancer cells under starvation conditions, giving a clue why disrupting RKIP signaling can promote metastasis. By contrast, autophagy prevents tumorigenesis by selectively removing damaged materials and intracellular organelles in normal and cancer cells. In this report, we briefly introduce the functional role of RKIP in cancer metastasis and its link to autophagy. Then, we summarize reports of the multiple direct and indirect RKIP-autophagy interactions. Linking RKIP to autophagy in cancer can help to better understand cancer metastasis and suggest new therapeutic targets.