Postdoc - Biomedicine

Co-Expression Network Analysis of AMPK and Autophagy Gene Products during Adipocyte Differentiation


Journal article


Mahmoud Ahmed, Jin Seok Hwang, Trang Huyen Lai, Sahib Zada, Huynh Quoc Nguyen, Trang Min Pham, Miyong Yun, Deok Ryong Kim
International Journal of Molecular Sciences, vol. 19(6), 2018 May 19

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APA
Ahmed, M., Hwang, J. S., Lai, T. H., Zada, S., Nguyen, H. Q., Pham, T. M., … Kim, D. R. (2018). Co-Expression Network Analysis of AMPK and Autophagy Gene Products during Adipocyte Differentiation. International Journal of Molecular Sciences, 19(6).

Chicago/Turabian
Ahmed, Mahmoud, Jin Seok Hwang, Trang Huyen Lai, Sahib Zada, Huynh Quoc Nguyen, Trang Min Pham, Miyong Yun, and Deok Ryong Kim. “Co-Expression Network Analysis of AMPK and Autophagy Gene Products during Adipocyte Differentiation.” International Journal of Molecular Sciences 19, no. 6 (May 19, 2018).

MLA
Ahmed, Mahmoud, et al. “Co-Expression Network Analysis of AMPK and Autophagy Gene Products during Adipocyte Differentiation.” International Journal of Molecular Sciences, vol. 19, no. 6, May 2018.


Abstract


Autophagy is involved in the development and differentiation of many cell types. It is essential for the pre-adipocytes to respond to the differentiation stimuli and may contribute to reorganizing the intracellulum to adapt the morphological and metabolic demands. Although AMPK, an energy sensor, has been associated with autophagy in several cellular processes, how it connects to autophagy during the adipocyte differentiation remains to be investigated. Here, we studied the interaction between AMPK and autophagy gene products at the mRNA level during adipocyte differentiation using public-access datasets. We used the weighted-gene co-expression analysis to detect and validate multiple interconnected modules of co-expressed genes in a dataset of MDI-induced 3T3-L1 pre-adipocytes. These modules were found to be highly correlated with the differentiation course of the adipocytes. Several novel interactions between AMPK and autophagy gene products were identified. Together, it is possible that AMPK-autophagy interaction is temporally and locally modulated in response to the differentiation stimuli.

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